Genomic Cloning of the Human Histo-Blood Group ABO Locus
نویسندگان
چکیده
منابع مشابه
Cloning of a rat gene encoding the histo-blood group B enzyme: rats have more than one Abo gene.
A genomic DNA fragment corresponding to exon 7 of the human ABO gene was amplified from rats of several inbred and outbred strains. Five different sequences were obtained, four of them corresponding to A-type sequences and one to a B-type sequence based on the amino acids equivalent to residues at positions 266 and 268 of the human enzymes. In rats from inbred strains, a single A-type sequence ...
متن کاملA new chemical approach to human ABO histo-blood group type 2 antigens.
A new chemical approach to synthesizing human ABO histo-blood type 2 antigenic determinants was developed. N-Phthaloyl-protected lactosaminyl thioglycoside derived from lactulose via the Heyns rearrangement was employed to obtain a type 2 core disaccharide. Use of this scheme lowered the overall number of reaction steps. Stereoselective construction of the α-galactosaminide/galactoside found in...
متن کاملThe ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis.
BACKGROUND AND OBJECTIVE ABO blood types are determined by antigen modifications on glycoproteins and glycolipids and associated with altered plasma levels of inflammatory and endothelial injury markers implicated in AKI pathogenesis. We sought to determine the association of ABO blood types with AKI risk in critically ill patients with trauma or sepsis. DESIGN, SETTING, PARTICIPANTS, & MEASU...
متن کاملExpression of human histo-blood group ABO genes is dependent upon DNA methylation of the promoter region.
We have investigated the regulatory role of DNA methylation in the expression of the human histo-blood group ABO genes. The ABO gene promoter region contains a CpG island whose methylation status correlates well with gene expression in the cell lines tested. The CpG island was found hypomethylated in some cell lines that expressed ABO genes, whereas the other cell lines that did not express ABO...
متن کاملThe effect of parental ABO blood group on fetal surveillance
Background Several factors may cause infertility and fetal loss. Blood groups antigens seem to be implied in the mechanisms of infertility and fetal loss. Maternal natural antibody can react against father’s blood group antigens on spermatozoa. The effects of parental blood group system on infertility and fetal surveillance perceived by its manifestation in prezygotic (caused infertility) and ...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 1995
ISSN: 0006-291X
DOI: 10.1006/bbrc.1995.1817